Tao Fu

Cryo-EM at 2.4 Å shows DNAJC13 as an antiparallel arch-shaped homodimer with a buried InsP6 pocket; dimerization controls WASH recruitment, tubule fission, and melanin production.

This study identifies how ERK, PKA, YAP/TAZ, and SHH signaling integrate to drive cortical lineage diversification and evolutionary expansion in the human cerebral cortex.

This study shows that Olig1/2 knockout in gliogenesis shifts glial precursor cells to produce non-proliferative interneurons instead of oligodendrocyte precursors, and identifies dorsal cortical GPCs as origin of H3.3G34R/V-mutant tumors.

The paper presents 545 silkworm genomes to explore genotype-phenotype relationships, identifying new genes and variants linked to domestication and adaptation.