Author

Kan Ding

Chinese Academy of SciencesORCID 0000-0002-8140-9259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Zhenyun Du· 3 shared Lulin HuangiD· 2 shared Wenfeng Liao· 2 shared Can JiniD· 1 shared Changlin MeiiD· 1 shared Chungwah Ma· 1 shared Dianxiu Cao· 1 shared Fei GuoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Zhenyun Du

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Hippocampal Glucuronyl C5-epimerase promotes stress resilience by directly engaging PI3K through a non-enzymatic mechanism

Meilin Chen, Lulin Huang, Songyu Yao, Jie Li, Fei He, Muya Xiong, Jianping Fang, Yanling Li, Yu Zhang, Wenfeng Liao, Zhenyun Du, Fei Guo, Tianyu Li, Jinjin Duan, Jing Nie, , Kan Ding

This study identifies Glce as a non-enzymatic regulator of hippocampal dendritic integrity and stress resilience through direct activation of PI3K, revealing a novel mechanism in depression pathophysiology.

bioRxiv · May 6, 2026 · PreprintNeuroscience

1,3- and 1,4-linked Polysaccharides Uptake in Intestinal Cells Relies on Clathrin/Dynamin 1/Rab5-dependent Endocytosis

Wenfeng Liao, Dianxiu Cao, Ying Wang, Zhenyun Du, Yao Jx, Pengfei Dou, Yuandong Zheng, Zhiming Wang, Xia Chen, Peipei Wang, Chungwah Ma, Hao Chen, Xingxing Diao, Kaiping Wang, Kan Ding

Orally administered β-1,3- and α-1,4-linked polysaccharides cross intestinal epithelium into rodent plasma and liver as macromolecules via clathrin-, dynamin 1-, and Rab5-dependent endocytosis mediated by EGFR, Dectin-1, and BMPRIA.

Nature Communications · Jan 26, 2026Peer-reviewedPharmacology & Toxicology✦ In-depth digest

D-glucuronyl C5-epimerase binds to EGFR to suppress kidney fibrosis

Xiaoqi Jing, Jun Wu, Jingru Ning, Xiaoyu Ding, Zhenyun Du, Xiaojiang Wang, Lulin Huang, Ran Wang, Changlin Mei, Kan Ding

This study identifies Glce as a key regulator of kidney fibrosis by binding to EGFR and inhibiting EMT through the TGF-β/Smad pathway, independent of its enzymatic activity.

Advanced Science · Aug 11, 2025Peer-reviewedPathology