Trauma, Hemostasis, Coagulopathy, Resuscitation

FRESH FROZEN PLASMA-BASED RESUSCITATION LESSENS LUNG INJURY IN MICE WITH ABDOMINAL SEPSIS AND HEMORRHAGIC SHOCK

This study shows that fresh frozen plasma reduces lung injury in mice with abdominal sepsis and hemorrhagic shock by preventing neutrophil degranulation and syndecan-1 shedding.

HS3ST1 regulates pulmonary inflammation and is a determinant of clinical outcomes after trauma and hemorrhagic shock

This study shows HS3ST1 deficiency worsens lung injury and increases mortality after trauma and hemorrhagic shock, particularly with fresh frozen plasma resuscitation.

Plasma regulates homeostatic pulmonary endothelial signaling to mitigate vascular leak following polytrauma and hemorrhagic shock

This study shows that fresh frozen plasma resuscitation after polytrauma and hemorrhagic shock reduces inflammation and preserves vascular barrier function by enhancing mitochondrial signaling and metabolic recovery in pulmonary endothelial cells.

Pattern of Circulating Mesenchymal Stromal Cells and Hematopoietic Progenitor and Stem Cells in the Peripheral Blood of Trauma Patients with and without Hemorrhagic Shock

The paper examines circulating mesenchymal stromal cells and hematopoietic progenitor/stem cells in trauma patients with and without hemorrhagic shock, finding that persistent early elevation of these cells and cytokines predicts worse outcomes.

A translational porcine model to assess the graded impact of hemorrhage and aortic occlusion on cardiovascular hemodynamics and renal perfusion

This study uses a porcine model to evaluate the effects of different aortic occlusion strategies on hemodynamics and renal perfusion during hemorrhagic shock.