Matthew Eden

A Microstructurally-Motivated Framework to Study Autoregulation in the Coronary Circulation

This paper develops a microstructurally-motivated model of coronary autoregulation that accurately reproduces hemodynamics and autoregulatory responses across myocardial depths.

Structural Lung Remodeling Precedes Functional Decline After Chronic Smoldering Douglas Fir Smoke Exposure in Apoe-/- Mice

This study shows that structural and molecular lung damage occurs before functional decline in mice exposed to smoke, highlighting the need for early biomarkers in firefighters.

Occupationally Relevant Wildfire Smoke Inhalation Impairs Nitric Oxide Signaling and Promotes Progressive Aortic Stiffening in Hypercholesterolemic Mice

This study shows that wildfire smoke exposure in hypercholesterolemic mice causes vascular inflammation, oxidative stress, and fibrosis, leading to aortic stiffening and hypertension.

A translational porcine model to assess the graded impact of hemorrhage and aortic occlusion on cardiovascular hemodynamics and renal perfusion

This study uses a porcine model to evaluate the effects of different aortic occlusion strategies on hemodynamics and renal perfusion during hemorrhagic shock.

Calibration of a Closed-loop Model of Porcine Aortic Hemodynamics during Hemorrhage

This study develops and calibrates a closed-loop 0D model of porcine aortic hemodynamics during hemorrhage, showing it can accurately reproduce experimental hemodynamic responses across different severities.

Co-Therapy with S1P and Heparan Sulfate Derivatives to Restore Endothelial Glycocalyx and Combat Pro-Atherosclerotic Endothelial Dysfunction

This study evaluates a therapy combining S1P and heparin to restore endothelial glycocalyx in disturbed flow conditions and improve vascular function.