Clostridium difficile and Clostridium perfringens research

Gnotobiotic OMM12 mice support sustained Clostridioides difficile colonization without antibiotic pretreatment

This study shows that gnotobiotic OMM12 mice can sustain Clostridioides difficile colonization for 20 days without antibiotic pretreatment, allowing research on host-microbiota-pathogen interactions.

Adaptation of the Geometric Viability assay as a high throughput assay to measure Clostridioides difficile spore germination

The paper adapts the Geometric Viability assay to measure C. difficile spore germination, finding it highly consistent with conventional methods and capable of detecting germination sensitivity differences.