Laurent Debarbieux

This study shows that gnotobiotic OMM12 mice can sustain Clostridioides difficile colonization for 20 days without antibiotic pretreatment, allowing research on host-microbiota-pathogen interactions.

This study identifies DNA-damaging bacteriocins from E. coli that induce prophages and promote lysogeny in the gut microbiota.

The paper investigates the 3D genome structuration and dynamics of bacteriophage PAK_P3 during infection of Pseudomonas aeruginosa, revealing specific interactions between phage and host genomes.

The paper describes an amyloid-based signal transduction mechanism in Escherichia coli's antiphage defense system, showing functional interchangeability between Bab and fungal HET-S amyloids.

This study uses computational models to show that phage cocktails targeting different bacterial receptors improve treatment outcomes in immunocompromised hosts and reduce resistance evolution.

This study investigates how phage-phage competition and biofilm formation affect the efficacy of a two-phage combination against Pseudomonas aeruginosa in vitro.

This study uses a spatially structured metapopulation model and in vivo experiments to evaluate how lung anatomy and immune responses affect the efficacy of phage therapy for Pseudomonas aeruginosa infections.