Bruno Dupuy

This study shows that gnotobiotic OMM12 mice can sustain Clostridioides difficile colonization for 20 days without antibiotic pretreatment, allowing research on host-microbiota-pathogen interactions.

This study shows that CDT toxin from Clostridioides difficile induces biofilm-like microcolonies, increasing colonization and persistence in intestinal models and infected mice.

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.