Clinical Laboratory Practices and Quality Control

Improving Turnaround Times with Artificial Intelligence in Microbiology

This study shows that AI software reduces urine culture turnaround times in microbiology labs, with significant improvements in both low- and high-volume settings.

Blood draw site and blood matrix influence mineral assessment

This study examines how blood draw site and matrix affect mineral concentrations in samples, finding significant variations in calcium, copper, iron, and magnesium levels between capillary/venous and plasma/serum samples.

Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays

This study compares five NfL immunoassays in plasma and CSF, finding four with excellent performance and noting assay-specific biases and correlations.

EDTA tubes are suitable for insulin and C-peptide measurement in resource-limited settings and can be stored at room temperature for up to 24 hours

This study shows that K2EDTA tubes allow stable insulin and C-peptide measurements at room temperature for up to 24 hours without immediate centrifugation.

COMPARISON OF UNIVARIATE AND MULTIVARIATE REFERENCE INTERVAL METHODS

This paper compares univariate and multivariate reference interval methods, finding that multivariate approaches reduce false positives and improve accuracy in clinical settings.

Freezing Diluted Bovine Serum Albumin Standards Does Not Significantly Affect Standard Curves

This study shows freezing diluted BSA standards at -20°C or -80°C and refreezing them up to three times does not significantly affect standard curves, making it a reliable method for protein quantification.

Analytical validation of the PROphet test for treatment decision-making guidance in metastatic non-small cell lung cancer

This study validates the analytical performance of the PROphet test, a plasma proteomics-based tool for NSCLC treatment decisions, showing high precision and cross-platform consistency.

Inadequate dried blood spot samples for Early Infant Diagnosis, how common and what are the reasons for rejection in Zimbabwe?

This study examines DBS sample rejection rates in Zimbabwe, finding 4% rejection with primary causes being insufficient volume and missing forms, and higher rejection rates at primary healthcare facilities.

Creating ethnicity-specific reference intervals for lab tests from EHR data

A novel method defines ethnicity-specific reference intervals for lab tests using EHR data, showing better prognostic value than existing intervals for serum creatinine and hemoglobin A1C.