This study compares five NfL immunoassays in plasma and CSF, finding four with excellent performance and noting assay-specific biases and correlations.

Clinical Chemistry and Laboratory Medicine (CCLM) · Sep 8, 2025Peer-reviewedNeuroscience

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank

Robert Francis Hillary, Danni A. Gadd, Zhana Kuncheva, Tasos Mangelis, Tin-Chi Lin, Kyle L. Ferber, Helen McLaughlin, Heiko Runz, Biogen Biobank Team, Eric Marshall, Riccardo Emilio Marioni, Christopher N. Foley, Benjamin B. Sun

This study identifies gene-environment interactions affecting plasma proteins in UK Biobank, discovering 683 vQTLs and over 1,400 GEIs across 571 proteins.

Nature Communications · Aug 26, 2024Peer-reviewedGenetic & Genomic Medicine

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi‐Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, , Christopher D. Whelan

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

Nature · Oct 4, 2023Peer-reviewedGenetics