Curcumin's Biomedical Applications

Genomic Discovery of EF-24 Targets Unveils Antitumorigenic Mechanisms in Leukemia Cells

This study identifies EF-24 targets and their antitumorigenic mechanisms in leukemia cells using whole-transcriptome profiling.

Nanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer

This study evaluates nanoparticle formulations of curcumin and piperine for modulating steroid biosynthesis in prostate cancer cells, finding that curcumin-piperine nanoparticles most effectively inhibit key enzymes and reduce androgen levels.

The chemopreventive effects of Curcumin against oxidative stress induced by Cadmium or H2O2 are mediated by Nrf2/ARE signaling and protective autophagy in myeloid cells

This study shows that curcumin protects myeloid cells from cadmium and H2O2-induced oxidative stress through Nrf2/ARE signaling and autophagy.

Non-micronized and micronized curcumin do not prevent the behavioral and neurochemical effects induced by acute stress in zebrafish

This study evaluates the effects of non-micronized and micronized curcumin on stress-induced behavioral and neurochemical changes in zebrafish, finding no protective effects.

Micronized curcumin causes hyperlocomotion in zebrafish larvae

This study shows that micronized curcumin increases locomotion in zebrafish larvae without affecting other behaviors or oxidative status.

Curcumin micronization by supercritical fluid: in vitro and in vivo biological relevance

This study compares the antioxidant effects of curcumin and micronized curcumin in vitro and in vivo, finding that micronization enhances antioxidant activity and mitigates stress-induced neurochemical changes in zebrafish.

Management of altered metabolic activity in Drosophila model of Huntington's disease by curcumin

This study shows curcumin improves metabolic issues in a Drosophila Huntington's disease model by reducing body weight abnormalities, lipid content, and ROS levels, and enhancing survival and locomotion.

In Silico Investigations on Curcuminoids from Curcuma longa as Positive Regulators of Wnt/β-catenin Signaling Pathway in Wound Healing

This study investigates the binding potential of curcuminoids to CK1 and GSK3B in the Wnt/β-catenin pathway using molecular docking and evaluates their drug likeness and pharmacological properties.

Modulation of proteasome activity by curcumin and didemethylcurcumin

This study shows curcumin and its derivative didemethylcurcumin modulate proteasome activity in a concentration-dependent biphasic manner, with curcumin being more effective.

Curcumin induces mild anemia in a DSS-induced colitis mouse model maintained on an iron-sufficient diet

This study shows curcumin causes mild anemia, lowers iron stores, worsens colitis, and reduces survival in DSS-induced colitis mice on an iron-sufficient diet.