Curcumin's Biomedical Applications

Curcumin-Magnesium complex loaded DNA hydrogels: concentration dependent swelling kinetics and selective cytotoxicity via Oxidative Stress induced apoptosis

This study develops Curcumin-Magnesium DNA hydrogels that show concentration-dependent swelling and induce oxidative stress-mediated apoptosis in cancer cells.

Curcumin Alleviates Systemic Inflammation and Gut Dysbiosis Induced by Circadian Rhythm Disruption in a Rodent Model of Jet Lag

Genomic Discovery of EF-24 Targets Unveils Antitumorigenic Mechanisms in Leukemia Cells

This study identifies EF-24 targets and their antitumorigenic mechanisms in leukemia cells using whole-transcriptome profiling.

Turmeric Phyto-NanoParticle (TPNP) enhances cellular bioavailability and anti-inflammatory effect of curcuminoids in human monocytes / macrophages

This paper develops Turmeric Phyto-NanoParticles (TPNPs) to enhance curcuminoid bioavailability and anti-inflammatory effects in human monocytes/macrophages.

Nanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer

This study evaluates nanoparticle formulations of curcumin and piperine for modulating steroid biosynthesis in prostate cancer cells, finding that curcumin-piperine nanoparticles most effectively inhibit key enzymes and reduce androgen levels.

Differential regulation of brain-specific molecular pathways is the reason for curcumin adult life-phase specific DAergic neuroprotection: Insights from ALSS Drosophila model of Parkinson disease

The paper shows curcumin protects dopaminergic neurons only in healthy adult Drosophila stages, not during aging transition, due to differential regulation of molecular pathways.

Curcumin Inhibition of DYRK Kinases

This paper investigates how curcumin interacts with DYRK1A and DYRK2 kinases, showing its potential to treat diabetes and cancer by modulating these proteins.

The chemopreventive effects of Curcumin against oxidative stress induced by Cadmium or H2O2 are mediated by Nrf2/ARE signaling and protective autophagy in myeloid cells

This study shows that curcumin protects myeloid cells from cadmium and H2O2-induced oxidative stress through Nrf2/ARE signaling and autophagy.

Non-micronized and micronized curcumin do not prevent the behavioral and neurochemical effects induced by acute stress in zebrafish

This study evaluates the effects of non-micronized and micronized curcumin on stress-induced behavioral and neurochemical changes in zebrafish, finding no protective effects.

Micronized curcumin causes hyperlocomotion in zebrafish larvae

This study shows that micronized curcumin increases locomotion in zebrafish larvae without affecting other behaviors or oxidative status.

Curcumin micronization by supercritical fluid: in vitro and in vivo biological relevance

This study compares the antioxidant effects of curcumin and micronized curcumin in vitro and in vivo, finding that micronization enhances antioxidant activity and mitigates stress-induced neurochemical changes in zebrafish.

Gene expression profiles of some prognostic markers in a human breast cell line (MCF7) exposed to Curcumin nanoparticles and nanocapsules

This study evaluates the effects of curcumin nanoparticles and nanocapsules on gene expression in MCF7 breast cancer cells, finding differences in apoptotic and oncogenic marker expression between the two formulations.

Management of altered metabolic activity in Drosophila model of Huntington's disease by curcumin

This study shows curcumin improves metabolic issues in a Drosophila Huntington's disease model by reducing body weight abnormalities, lipid content, and ROS levels, and enhancing survival and locomotion.

In Silico Investigations on Curcuminoids from Curcuma longa as Positive Regulators of Wnt/β-catenin Signaling Pathway in Wound Healing

This study investigates the binding potential of curcuminoids to CK1 and GSK3B in the Wnt/β-catenin pathway using molecular docking and evaluates their drug likeness and pharmacological properties.

Modulation of proteasome activity by curcumin and didemethylcurcumin

This study shows curcumin and its derivative didemethylcurcumin modulate proteasome activity in a concentration-dependent biphasic manner, with curcumin being more effective.

Curcumin induces mild anemia in a DSS-induced colitis mouse model maintained on an iron-sufficient diet

This study shows curcumin causes mild anemia, lowers iron stores, worsens colitis, and reduces survival in DSS-induced colitis mice on an iron-sufficient diet.