Amit V. Pandey

Dual-portal ligand transport in human cytochrome P450 17A1

This study identifies two distinct portals for ligand transport in CYP17A1 using molecular dynamics and experimental validation, showing that both are required for catalytic activity.

Analysis of single nucleotide substitution in CYP21A2 gene using Alphagenome

The paper analyzes single nucleotide substitutions in the CYP21A2 gene using AlphaGenome to connect clinical annotations, population data, splicing predictions, and enzyme function.

Nanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer

This study evaluates nanoparticle formulations of curcumin and piperine for modulating steroid biosynthesis in prostate cancer cells, finding that curcumin-piperine nanoparticles most effectively inhibit key enzymes and reduce androgen levels.

Structural and Evolutionary Analysis of Human Growth Hormone Variants

The paper analyzes human growth hormone variants to identify critical residues for GH-GHR interaction and disease-causing mutations.

Meta analysis of variant predictions in congenital adrenal hyperplasia caused by mutations in CYP21A2.

The paper evaluates in silico variant predictors for CYP21A2 SNVs, finding high accuracy for severe phenotypes but variability for mild ones.

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

The paper develops an in silico workflow to predict molecular targets of natural products and identifies four new targets for dihydrochalcones.