Youngki You

Carbamylome analysis reveals regulatory roles for lysine carbamylation in β-cell glycolytic and insulin-processing enzymes

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

Oligomeric assemblies of plant biotin carboxylase revealed by cryo-EM and cross-linking

This study uses cryo-EM and cross-linking to reveal the oligomeric structure of plant biotin carboxylase, showing asymmetric dimer-of-dimers and dynamic B-domain interactions.

PTMOverlay: A Proteomic Tool to Visualize Post-Translational Modifications Across Evolution

PTMOverlay visualizes post-translational modifications across species by aligning PTM sites to protein sequences, revealing conserved modifications in bacterial central carbon metabolism.

Efficient genetic code expansion tools enable in vivo study of lysine acetylation in non-model bacteria

This paper develops a genetic code expansion platform for in vivo study of lysine acetylation in non-model bacteria, demonstrating its use in a non-E. coli strain.

Regulation of bacterial stringent response by an evolutionary conserved ribosomal protein L11 methylation

The paper identifies conserved bacterial protein methylation, showing ribosomal protein L11 methylation regulates stringent response signaling and ribosomal homeostasis.

Modulation of proteasome activity by curcumin and didemethylcurcumin

This study shows curcumin and its derivative didemethylcurcumin modulate proteasome activity in a concentration-dependent biphasic manner, with curcumin being more effective.