Infective Endocarditis Diagnosis and Management

Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection

The paper uses a physics model to show weakened heart contractility increases bacterial invasion risk in cardiac organoids, with mouse experiments confirming a 80% reduction in endocarditis risk with increased contractility.

A novel infective endocarditis virulence factor related to multiple functions for bacterial survival in blood was discovered in Streptococcus sanguinis

This study identifies SSA_0451 as a novel virulence factor in Streptococcus sanguinis that enhances survival in blood by mitigating oxidative and environmental stress.