Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection
Anheng Wang, jiaxian wang, Zhe Zhang, Chunli Yang, Chunhao Deng, Guokai Chen, Chengwu Li, Qian Wang, Lei Dong, Chunming Wang
The paper uses a physics model to show weakened heart contractility increases bacterial invasion risk in cardiac organoids, with mouse experiments confirming a 80% reduction in endocarditis risk with increased contractility.
bioRxiv · Apr 8, 2025 · PreprintBioengineering