Inhalation and Respiratory Drug Delivery

Vehiculation and functional delivery of lipophilic therapeutics and antibiotics via pulmonary surfactant in a lung-on-chip model

This study demonstrates the use of a lung-on-chip model to study drug vehiculation via pulmonary surfactant, showing effective delivery and suppression of Mycobacterium tuberculosis.

Pharmaceutical assessment of low global warming potential alternatives to HFA-134a in a budesonide, glycopyrrolate, and formoterol fumarate pressurized metered dose inhaler

This paper evaluates HFO-1234ze(E) as a low-GWP alternative to HFA-134a for reformulating a budesonide, glycopyrrolate, and formoterol fumarate pMDI, showing better stability and aerosol characteristics than HFA-152a.

Computational Fluid Particle Dynamics-Informed Machine Learning Prototype for a User-Centered Smart Inhaler Enabling Uniform Drug Delivery to Small Airways

This paper develops a machine learning framework informed by computational fluid dynamics to optimize inhaler nozzle design for uniform drug delivery to small airways.

Eulerian-Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model

This paper models drug delivery in the lungs under varying breathing conditions, showing COPD patients have different drug deposition patterns compared to healthy individuals.

Phase-separating enzyme-responsive condensates for inhalable delivery of biomacromolecules

This paper develops enzyme-responsive condensates for inhaled delivery of biomacromolecules, enabling controlled release and targeted cell regulation.

Open-source 3D printed manifolds for exposure studies using human airway epithelial cells

This paper presents open-source 3D printed manifolds for uniform airborne exposure of airway epithelial cells in vitro, showing reduced variation in aerosol deposition and functional responses to cannabis and tobacco smoke.

Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia

This study evaluates nebulized flagellin as a therapeutic for antibiotic-resistant pneumococcal pneumonia, showing it enhances immune response and synergizes with amoxicillin in mice.