Ronan J. MacLoughlin

Local tolerance and innate immune activation of primary human respiratory cells exposed to flagellin

This study evaluates the tolerance and innate immune response of human respiratory epithelial cells to FLAMOD, a flagellin-based therapy, showing dose-dependent activation of immune pathways without tissue damage.

Flagellin nebulization enhances respiratory immune responses in the porcine model

This study shows that nebulized FLAMOD, a flagellin agonist, induces a robust immune response in pigs without adverse effects, highlighting innate immunity and bacterial defense pathways.

Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia

This study evaluates nebulized flagellin as a therapeutic for antibiotic-resistant pneumococcal pneumonia, showing it enhances immune response and synergizes with amoxicillin in mice.