Distinct and cooperative roles of host and tumor Osteopontin in colorectal cancer liver metastasis
Patrick Czabala, Yang Zhao, John David Klement, Priscilla S. Redd, Dakota B. Poschel, Kristen Carver, Kendra Fick, Zainab A. Tiamiyu, Martina Zoccheddu, Patricia Veronica Schoenlein, Jennifer L. Waller, Huidong Shi, Kebin Liu
This study investigates the distinct and cooperative roles of host and tumor-derived Osteopontin in colorectal cancer liver metastasis using genetic knockout models and spatial transcriptomics.
bioRxiv · Feb 20, 2026 · PreprintImmunology