Bone and Dental Protein Studies

Chemical Maturation Controls Bioavailability of Fetuin-A-Mineral Complexes in Biomineralization

The paper shows that Fetuin-A mineral complexes exist in distinct states with different mineral bioavailability, controlled by chemical maturation.

Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC

This study shows that suppressing SPP1 improves cisplatin sensitivity and inhibits tumor invasion and metastasis in NRF2-hyperactivated cisplatin-resistant HNSCC.

Distinct and cooperative roles of host and tumor Osteopontin in colorectal cancer liver metastasis

This study investigates the distinct and cooperative roles of host and tumor-derived Osteopontin in colorectal cancer liver metastasis using genetic knockout models and spatial transcriptomics.

Bone mechano-response is driven by locomotion transitions during vertebrate evolution

This study identifies non-collagenous bone matrix proteins as regulators of bone mechano-response, showing evolutionary transitions in locomotion shaped their roles in humans.

Poly(ADP-ribose) binding sites on collagen I fibrils for nucleating intrafibrillar bone mineral

Posteruptive Loss of Enamel Proteins Concurs with Gain in Enamel Hardness

This study examines how protein content in porcine enamel decreases after eruption, correlating with increased enamel hardness and saliva enzyme activity.

The collagen-binding epitopes of Drosophila SPARC are essential for survival and collagen IV distribution and assembly into basement membranes

This study shows that SPARC's collagen-binding epitopes are essential for Drosophila survival and proper collagen IV distribution and basement membrane assembly.

Accurate informatic modeling of tooth enamel pellicle interactions by training substitution matrices with Mat4Pep

The paper develops a substitution matrix-based method to model tooth enamel pellicle peptide interactions with hydroxyapatite, achieving high discrimination accuracy.