Chemotherapy-Induced Oral Mucosal Injury Is Defined by p53 Activation, Cell Cycle Arrest and Diverse Epithelial Progenitor Dynamics
Pedro H F SILVA, Lei Li, Madison Muriel, Tara Brennan, Md Hasanuzzaman, Mariadela Demoura, Joleene Stampfer, Michele Sveinsson, Christos K Fountzilas, Jill E. Schabert, Anurag K. Singh, Jonathan Bard, Nicolas F. Schlecht, Laertis Ikonomou, Patricia I. Diaz
In 5-FU-treated mice, oral and intestinal epithelial atrophy stems from p53-linked cell cycle arrest, not apoptosis, while a chemoresistant AP-1/p53 basal cluster expands in tongue.
bioRxiv · Sep 11, 2026 · PreprintCell Biology✦ In-depth digest