Jonathan Bard

This study identifies Myo9b's role in regulating epithelial brush border microvilli through RhoA signaling and shows that a disease variant disrupts microvilli formation in human cells.

In 5-FU-treated mice, oral and intestinal epithelial atrophy stems from p53-linked cell cycle arrest, not apoptosis, while a chemoresistant AP-1/p53 basal cluster expands in tongue.

This study shows ATF6α regulates lung aging and remodeling in specific cell types, with distinct effects on epithelial mitochondrial function and pericyte fibrosis.

The paper identifies regulatory elements controlling Ets1 expression in B cells but not T cells, using epigenetic and reporter assays in mice.

This study identifies key transcription factors that regulate the epigenetic landscape during retinal cell differentiation using scATAC-seq and CUT&Tag.

The paper identifies mutation signatures associated with MMR pathway defects by combining rnr1 and msh mutations, revealing novel repair substrate specificities of Msh2-Msh3 and Msh2-Msh6 complexes.

The paper uses single-cell RNA-seq to analyze retinal ganglion cell lineage development in wild-type and Atoh7-null retinas, revealing a transitional cell state and revised understanding of Atoh7's role.

The paper develops a targeted sequencing approach to analyze mutation profiles in yeast and identifies genotype-specific variants influenced by dNTP pool changes.