Christos K Fountzilas

In 5-FU-treated mice, oral and intestinal epithelial atrophy stems from p53-linked cell cycle arrest, not apoptosis, while a chemoresistant AP-1/p53 basal cluster expands in tongue.

This paper develops a sequential triple-drug strategy targeting p53 mutant cancers, showing it effectively induces cell death while minimizing toxicity to normal cells.