Heparin-Induced Thrombocytopenia and Thrombosis

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT

This study investigates how ChAdOx1 transduces endothelial cells and binds PF4, finding it binds PF4 but does not activate endothelial cells, suggesting a need for PF4-binding capsid modifications to reduce VITT risk.

Antithrombotic Efficacy and Bleeding Risks of Vaccine-Induced Immune Thrombotic Thrombocytopenia Treatments

This study evaluates anticoagulants and IVIg for treating VITT, finding danaparoid reduces IgG-PF4 binding and FcγRIIa blockade is most effective for thrombosis and thrombocytopenia.

The Structure of ChAdOx1/AZD-1222 Reveals Interactions with CAR and PF4 with Implications for Vaccine-induced Immune Thrombotic Thrombocytopenia

The paper determines the structure of the ChAdOx1 adenovirus vector and identifies interactions with CAR and PF4, proposing a mechanism for vaccine-induced immune thrombotic thrombocytopenia.