The Structure of ChAdOx1/AZD-1222 Reveals Interactions with CAR and PF4 with Implications for Vaccine-induced Immune Thrombotic Thrombocytopenia
Alexander T. Baker, Ryan J. Boyd, Daipayan Sarkar, Alicia Teijeira, Chun Kit Chan, Emily Bates, Kasim Waraich, John Vant, Eric Wilson, Chloe Du Truong, Magdalena Lipka‐Lloyd, Petra Fromme, Josh V. Vermaas, Dewight Williams, LeeAnn Machiesky, , Mitesh J. Borad
The paper determines the structure of the ChAdOx1 adenovirus vector and identifies interactions with CAR and PF4, proposing a mechanism for vaccine-induced immune thrombotic thrombocytopenia.
Science Advances · Dec 1, 2021Peer-reviewedMolecular Biology