Steven Edward McKenzie

This study evaluates anticoagulants and IVIg for treating VITT, finding danaparoid reduces IgG-PF4 binding and FcγRIIa blockade is most effective for thrombosis and thrombocytopenia.

This study creates a mouse model of the PAR4-P310L variant and shows reduced platelet reactivity to PAR4-activation peptide and thrombin, with no effect on ADP and convulxin responses.

This study shows that Plk3 promotes bacterial spread and sepsis by enabling bacteremia, as Plk3-deficient mice survive sepsis models with reduced bacterial load in blood.