Mitesh J. Borad

This study identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomas using genomic, transcriptomic profiling, and drug testing in patient-derived models.

This study identifies AKT as a regulator of YAP stability and shows that AKT inhibition triggers ESCRT-dependent YAP degradation, enhancing the efficacy of RAS inhibition in pancreatobiliary cancers.

Oncolytic virus-based delivery of an alloantigen improves antitumor immunity and synergizes with immune checkpoint inhibitors in pancreatic cancer.

This study identifies biomarkers and resistance mechanisms to SFK-YAP inhibition in cholangiocarcinoma using multiomic profiling and shows synergy with chemotherapy.

A glycoprotein-engineered vesiculovirus platform circumvents neutralizing antibodies, enabling repeat intravenous dosing and sustained anti-tumor immunity in preclinical models.

The paper investigates the functional impact of the HyperDuplication GenomoPhenotype in high copy number endometrial cancer, showing it enhances tumor fitness and therapy resistance through coordinated duplication of oncogenes.

The paper identifies a potent MET degrader using live cell imaging, showing it is more effective than existing PROTACs.

Analyzing the positioning and nucleotide sequence at fragment ends in plasma DNA may enable cancer diagnostics.

The paper determines the structure of the ChAdOx1 adenovirus vector and identifies interactions with CAR and PF4, proposing a mechanism for vaccine-induced immune thrombotic thrombocytopenia.

OCEANS improves nanopore sequencing for detecting low VAF somatic mutations with high accuracy and sensitivity in clinical samples.

The paper evaluates pre-analytical factors affecting plasma DNA analysis by comparing DNA extraction methods and blood collection tubes using a multiplexed ddPCR assay.