Pneumocystis jirovecii pneumonia detection and treatment

Predicting antifolate resistance in the unculturable fungal pathogen Pneumocystis jirovecii

This paper trains a machine learning model to predict antifolate resistance mutations in Pneumocystis jirovecii using experimental data and computational modeling, finding mutations that confer resistance to trimethoprim-sulfamethoxazole.

Extracellular Vesicle-Mediated Delivery of Genetic Material for Transformation and CRISPR/Cas9-based Gene Editing in Pneumocystis murina

This paper develops a method to genetically modify Pneumocystis murina using extracellular vesicles for CRISPR/Cas9 delivery, achieving stable in vivo gene editing and transgene expression.

Single-Cell RNA Sequencing Defines Developmental Progression and Reproductive Transitions of Pneumocystis carinii

This study uses scRNA-seq to map the life cycle of Pneumocystis carinii, identifying transcriptional states associated with developmental stages and reproductive transitions.

Pneumocystis murina Promotes Inflammasome Formation and NETosis during Pneumocystis Pneumonia

This study identifies NLRP3 inflammasome activation and NETosis in P. murina pneumonia, highlighting neutrophils' role in inflammation and tissue damage.

Diversity and complexity of the large surface protein family in the compacted genomes of various Pneumocystis species

The paper characterizes the diversity and evolution of the Msg gene superfamily across Pneumocystis species, revealing its functional roles in immune evasion and host adaptation.