Hidradenitis Suppurativa and Treatments

Computational discovery of precision therapeutics for hidradenitis suppurativa

A data-driven precision medicine approach identifies sirolimus, pioglitazone, and fulvestrant as novel therapies for hidradenitis suppurativa by targeting disease gene signatures in immune cells.

Metabolic Repression of Autophagy Drives Inflammation, Pain, and Malodor in Hidradenitis Suppurativa

This study identifies metabolic dysregulation of autophagy in HS, linking mTOR activation and cadaverine to inflammation, pain, and malodor.

Pathogenic Keratinocyte States and Fibroblast Niches Define the Tissue Microenvironment in Severe Hidradenitis Suppurativa

This study uses single-cell RNA-sequencing and spatial transcriptomics to characterize keratinocyte states and fibroblast niches in severe HS lesions, revealing spatially distinct interactions that may explain treatment resistance.