Michael D. Rosenblum

This study identifies CD38 as a regulator of interferon responses in juvenile dermatomyositis and suggests its inhibition as a potential therapeutic strategy.

This study uses spatial transcriptomics across mouse, dog, and human to identify conserved T cell-hair follicle interactions in PCA, revealing potential drug targets.

The paper identifies CD8+ T cells as key drivers of fibrosis in morphea-spectrum diseases through fibroblast IFN-γ signaling using spatial transcriptomics.

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

A data-driven precision medicine approach identifies sirolimus, pioglitazone, and fulvestrant as novel therapies for hidradenitis suppurativa by targeting disease gene signatures in immune cells.

This study identifies layilin as a regulator of Treg motility and suppressive capacity in skin, showing its role in adhesion and inflammation.

This paper develops a whole-tissue explant model of hidradenitis suppurativa to study its pathogenesis and treatment efficacy in intact human tissue.

This study compares the skin colonization of Candida auris and C. albicans, finding that C. auris induces IFNγ to enhance its colonization of hair follicles by impairing keratinocyte function.

This study examines the effects of secukinumab on transcriptomic changes in psoriatic skin and T cell subsets over 12 weeks, showing significant reduction in IL17A and related genes.