Chris Cheshire

This study uses single-cell RNA-sequencing and spatial transcriptomics to characterize keratinocyte states and fibroblast niches in severe HS lesions, revealing spatially distinct interactions that may explain treatment resistance.

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

Flow provides a web platform and database for managing and analyzing large-scale bioinformatics data, addressing challenges in data processing, quality, and accessibility.

The paper uses single-cell RNA sequencing to study cell fate decisions at the neural plate border in chick ectoderm, proposing a gradient border model for fate allocation.