Parvovirus B19 Infection Studies

Identification of Human Transferrin Receptor as an Entry Co-receptor for Parvovirus B19 Infection of Human Erythroid Progenitor Cells

This study identifies human transferrin receptor 1 (hTfR) as a co-receptor for parvovirus B19 (B19V) entry into erythroid progenitor cells, showing that hTfR binding to the viral VP1u protein is critical for viral internalization and replication.

Transferrin receptor 1 binds human parvovirus B19 VP1u to facilitate entry

This study identifies transferrin receptor 1 as the receptor for human parvovirus B19 VP1u, demonstrating its role in virus entry through direct binding and uptake inhibition.

Cellular determinants of parvovirus B19 infection in the human placenta

This study identifies the cellular receptors and factors that determine parvovirus B19 infection in human placental trophoblasts, showing that VP1uR, globoside, and proliferative activity are key, while EpoR signaling is not required.

Globoside is an essential intracellular factor required for parvovirus B19 endosomal escape in erythroid progenitor cells

This study identifies globoside as an essential receptor for parvovirus B19 endosomal escape, challenging the existing model of membrane disruption by PLA2 activity.