Mario Mietzsch

This study identifies human transferrin receptor 1 (hTfR) as a co-receptor for parvovirus B19 (B19V) entry into erythroid progenitor cells, showing that hTfR binding to the viral VP1u protein is critical for viral internalization and replication.

This study identifies AAV2's ability to bundle actin filaments, suggesting a new class of actin-binding viruses and offering insights for improving AAV gene therapy.

This study examines how acetylation and phosphorylation mutations affect tau aggregation and seeding in Alzheimer's and PSP models.

This study uses cryo-EM to analyze antibodies against AAV9 vectors, identifying residues that enable capsid engineering to avoid neutralization and allow redosing.

This study improves AAV vector genome packaging efficiency by engineering Rep hybrid proteins, reducing empty capsids and increasing full capsid yields across non-AAV2 serotypes.