Ablation of Prdm16 and beige fat causes vascular remodeling and elevated blood pressure
Mascha Koenen, Tobias Becher, Giulia Pagano, Ilaria Del Gaudio, Jorge A. Barrero, Augusto C. I. Montezano, Jenelys Ruiz Ortiz, Zeran Lin, Nicolás Gómez-Banoy, Rose Amblard, Daniel Schriever, Meltem Ece Kars, Luisa Rubinelli, Sarah J Halix, Zhen Fang Huang Cao, , Paul Cohen
Adipocyte-specific deletion of Prdm16 ablates beige fat identity, derepresses the secreted enzyme Qsox1, and induces vascular fibrosis, angiotensin II hyperreactivity, and elevated blood pressure in mice.
Science · Jan 15, 2026Peer-reviewedPhysiology✦ In-depth digest