Synthesis and Biological Evaluation

Synthesis of Novel N-Substituted β-Amino Acid Derivatives Bearing 2-Hydroxyphenyl Moieties as Promising Antimicrobial Candidates Targeting Multidrug-Resistant Gram-Positive Pathogens

This study synthesizes and tests new N-substituted β-amino acid derivatives with 2-hydroxyphenyl groups against multidrug-resistant Gram-positive bacteria, finding some compounds show promising antimicrobial activity.

2,3-bis (phenylamino) quinoxaline - containing compounds display potent activity against Methicillin-resistant Staphylococcus aureus, Enterococcus faecalis and their biofilms

This study identifies two quinoxaline derivatives with potent antibacterial activity against MRSA, VRE, and their biofilms, showing comparable or better efficacy than existing antibiotics.