Topic · Infectious Diseases · Medicine

Infectious Encephalopathies and Encephalitis

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

Central nervous system-derived inflammasome cytokines drive neuroglial injury and cerebral oedema in viral encephalitis, despite corticosteroid therapy

Franklyn Nkongho Egbe, Cordelia Dunai, Claire Hetherington, Sarah A. Boardman, Laura Bricio-Moreno, Bethany Facer, Cory Hooper, David Haw, Alexandra–Chloé Villani, Luca Lenzi, Sam T. Haldenby, Sally O. Oswald, Steve Patterson, Evelyn Kurt-Jones, Andrew David Luster, , Benedict Daniel Michael

This study identifies IL-1 and IL-6 as key drivers of neuroinflammation in HSV encephalitis, showing they are not reduced by corticosteroids and are associated with poor outcomes.

bioRxiv · Oct 10, 2025 · PreprintNeuroscience

Enhanced virus detection and metagenomic sequencing in patients with meningitis and encephalitis

Anne L Piantadosi, Shibani S. Mukerji, Simon H. Ye, Michael J. Leone, Lisa M. Freimark, Daniel J. Park, Gordon C. Adams, Jacob E. Lemieux, Sanjat Kanjilal, Isaac H. Solomon, Asim A. Ahmed, Robert H. Goldstein, Vijay Ganesh, Bridget Ostrem, Kaelyn C. Cummins, , Pardis Christine Sabeti

This study uses metagenomic sequencing to detect pathogens in CNS infections, identifying novel pathogens and improving detection methods.

mBio · Aug 31, 2021Peer-reviewedNeuroscience

Improved diagnosis of viral encephalitis in adult and pediatric hematological patients using viral metagenomics

Ellen C. Carbo, Emilie P. Buddingh, Evita Karelioti, Igor A. Sidorov, Mariet C.W. Feltkamp, Peter A. von dem Borne, Jan J.G.M. Verschuuren, Aloys C.M. Kroes, Eric C. J. Claas, Jutte J.C. de Vries

This study improves viral encephalitis diagnosis in hematological patients using viral metagenomics with capture probes, detecting viruses missed by routine tests.

Journal of Clinical Virology · Jul 31, 2020Peer-reviewedGenomics