Jan J.G.M. Verschuuren

IgG4 antibody repertoire diversity is stable over several years in health and autoimmune disease

The paper examines IgG4 antibody repertoire stability over time in health and autoimmune diseases, finding that most clones remain stable despite treatment.

MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificity

This study investigates how valency and epitope specificity of MuSK antibodies affect MuSK signaling, revealing distinct impacts on binding kinetics, Dok7 binding, and gene expression.

Distinct transcriptional programs define human IgG4+ memory B cells

This study identifies distinct transcriptional programs in human IgG4+ memory B cells, revealing unique features and potential therapeutic targets.

Patient-specific therapeutic benefit of MuSK agonist antibody ARGX-119 in MuSK myasthenia gravis passive transfer models

This study shows that the MuSK agonist antibody ARGX-119 can rescue MuSK myasthenia gravis in a patient-specific manner, with efficacy linked to the presence of MuSK activating antibodies in some patients.

Improved diagnosis of viral encephalitis in adult and pediatric hematological patients using viral metagenomics

This study improves viral encephalitis diagnosis in hematological patients using viral metagenomics with capture probes, detecting viruses missed by routine tests.