Connective Tissue Growth Factor Research

Cell Communication Network factor 4 promotes tumor-induced immunosuppression in breast cancer.

This study shows that CCN4 promotes immunosuppression in breast cancer by altering the tumor microenvironment and immune cell composition.

WISP2/CCN5 gene knockdown in vitro and in vivo exhibits proliferation promotion of breast cancer through targeting Skp2 and p27Kip1

This study shows that knocking down WISP2/CCN5 promotes breast cancer cell proliferation by upregulating Skp2 and downregulating p27Kip1.

A CTGF-YAP regulatory pathway is essential for angiogenesis and barriergenesis in the retina

This study identifies the CTGF-YAP pathway as critical for vascular development and barrier function in the retina.