Topic · Physiology · Biochemistry, Genetics and Molecular Biology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
33 papers
Ninghai Gan, Yan Han, Weizhong Zeng, Youxing Jiang
This study identifies allosteric mutations and lipid interactions that modulate TRPML1 channel function, revealing structural insights into its regulation by lipids and potential therapeutic targets.
eLife · Oct 14, 2024Peer-reviewedBiophysics
Madison Sangster, Sanjid Shahriar, Zachary Niziolek, Maria Carla Carisi, Michael Lewandowski, Bogdan Budnik, Yulia Grishchuk
The paper uses cell type-specific proteomics in a MLIV mouse model to identify molecular mechanisms and dysregulated pathways in different brain cell types.
Frontiers in Molecular Neuroscience · Aug 7, 2023Peer-reviewedNeuroscience
Dongun Lee, Dong Min Shin, Jeong Hee Hong
This study shows that reduced chloride levels trigger lysosomal calcium release via TRPML1, affecting migration and apoptosis, and identifies chloride-sensing motifs in TRPML1.
Cells · Jul 12, 2023Peer-reviewedMolecular Biology