Author

Weizhong Zeng

Howard Hughes Medical InstituteORCID 0000-0002-9636-2086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Youxing JiangiD· 4 shared Jing XueiD· 2 shared Yan HaniD· 2 shared Celso M. Teixeira‐DuarteiD· 1 shared Jianghuang WangiD· 1 shared Li ZhangiD· 1 shared Michela OttoliaiD· 1 shared Nicole Attiq· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiophysics

Youxing JiangORCID

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4 papers

Recent·Most cited

Molecular mechanisms of mitochondrial Ca2+ exchanger NCLX

Li Zhang, Yan Han, Weizhong Zeng, Jing Xue, Yan Wang, Youxing Jiang

This study reports cryo-EM structures of rat NCLX in different states, revealing its ion exchange mechanism and structural similarities to NCXs.

Nature Communications · Jul 10, 2026Peer-reviewedBiophysics

Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload

Celso M. Teixeira‐Duarte, Wan Fu, Weizhong Zeng, Jianghuang Wang, Xinzhe Jiang, Ziye Zhao, Qing Zhong, Youxing Jiang

This study identifies the molecular mechanism of Necrocide 1 activation of human TRPM4 and explains its species-specific selectivity using cryo-EM, electrophysiology, and cell death assays.

Nature Communications · Jun 24, 2026Peer-reviewedBiophysics

Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

Jing Xue, Weizhong Zeng, Scott John, Nicole Attiq, Michela Ottolia, Youxing Jiang

This study presents cryo-EM structures of human NCX1 with PIP2 and SEA0400, revealing how these molecules modulate NCX1 activity through conformational changes.

bioRxiv · Dec 5, 2024Biophysics

TRPML1 gating modulation by allosteric mutations and lipids

Ninghai Gan, Yan Han, Weizhong Zeng, Youxing Jiang

This study identifies allosteric mutations and lipid interactions that modulate TRPML1 channel function, revealing structural insights into its regulation by lipids and potential therapeutic targets.

eLife · Oct 14, 2024Peer-reviewedBiophysics