Yan Han

This study reports cryo-EM structures of rat NCLX in different states, revealing its ion exchange mechanism and structural similarities to NCXs.

The paper identifies CEND1 as a regulator of activity-dependent glucose metabolism by facilitating mitochondrial ATP channeling to hexokinase I.

This study identifies Adig as a regulator of lipid droplet formation by stabilizing the dodecameric seipin complex, leading to increased fat mass and thermogenesis in mice.

This paper identifies new drug targets in Schistosoma mansoni using a genome-scale pipeline and discovers a p97 allosteric binding site that could lead to species-selective inhibitors.

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

This study identifies allosteric mutations and lipid interactions that modulate TRPML1 channel function, revealing structural insights into its regulation by lipids and potential therapeutic targets.

The paper reports the cryo-EM structure of the yeast SWI/SNF chromatin remodeling complex bound to a nucleosome, revealing its architecture and interactions with histones.