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Neurological Disease Mechanisms and Treatments

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Oligodendrocyte stress response as a driver of vascular dementia

Emeric Merour, Trupti Ghatage, Cole Corbett, Matthew DeBerge, Rejani Kunjamma, Ian Steckler Ian Steckler, Moones Heidari, Farzaneh A. Sorond, Margaret E. Flanagan, Edward Benjamin Thorp, Brian Popko

This study identifies oligodendrocyte stress response as a driver of vascular dementia by showing its role in myelin damage and cognitive impairments in mice and humans.

bioRxiv · Oct 13, 2026 · PreprintNeuroscience

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