Matthew DeBerge

This study identifies oligodendrocyte stress response as a driver of vascular dementia by showing its role in myelin damage and cognitive impairments in mice and humans.

The paper identifies conserved molecular responses to cardiometabolic stress across different disease models and finds PAI-1 as a key mediator of cardiac remodeling.

This study shows that myeloid Hif1 is essential for neonatal cardiac regeneration via IGF-1 signaling, as its loss impairs regenerative function and increases myocardial scarring.

This study shows that microglial metabolic reprogramming in HFpEF drives neuroinflammation and cognitive decline, with HIF-1 signaling as a key mediator.