Edward Benjamin Thorp

This study identifies oligodendrocyte stress response as a driver of vascular dementia by showing its role in myelin damage and cognitive impairments in mice and humans.

This study shows that loss of Smyd5 in cardiomyocytes causes inflammation and heart failure in mice by reducing H4K20me3 and increasing Il-6 expression.

The paper develops RNA nanotherapeutics targeting TAMC cholesterol metabolism to enhance anti-tumor immunity in glioblastoma.

This study shows that myeloid Hif1 is essential for neonatal cardiac regeneration via IGF-1 signaling, as its loss impairs regenerative function and increases myocardial scarring.

This study identifies endothelial PHD3 as a regulator of kidney repair after ischemia, showing its role in suppressing inflammation and fibrosis through HIF-dependent mechanisms.

This study shows that APOL1 G1 and G2 risk alleles affect diet-induced obesity severity differently in male and female transgenic mice.

This study shows H19 upregulation in HLHS impairs mitophagy and increases ischemic vulnerability in immature hearts and cardiomyocytes.

This study shows G1 and G2 APOL1 variants increase macrophage inflammation and lipid accumulation via the polyamine pathway, which can be inhibited by DFMO.

This study identifies tissue-resident skeletal muscle macrophages that support muscle recovery from viral pneumonia in aging mice, with Mertk playing a key role.

This study shows that inactivating PHD enzymes in endothelial cells after ischemic kidney injury promotes maladaptive repair through glycolysis and MCT4, which can be reversed by MCT4 inhibitors.

The paper identifies age-specific secretome differences in macrophages under hypoxia and LPS, showing neonatal macrophages have anti-inflammatory, regenerative properties dependent on HIF-1, while adult macrophages show pro-inflammatory, glycolytic responses.