In situ radiation damage tracking during scanning small-angle X-ray scattering
Boram Yu, Rita Mended sa Silva, M. S. Sinha…·Sarah Köster
This paper tracks radiation damage in cells during scanning SAXS using a synchronized brightfield microscope.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Boram Yu, Rita Mended sa Silva, M. S. Sinha…·Sarah Köster
This paper tracks radiation damage in cells during scanning SAXS using a synchronized brightfield microscope.
Haining Wang, Hengyi Fu, Zuoyu Tian
This paper evaluates the impact of NIH's K23 trial pathway on trial leadership, finding increased K-trial leadership but no significant increase in new trials.
Josephine T Tagestad, J Patrick Kelley, Camilo Alfonso, Corey E. Tarwater
The study finds that male red-capped manakins discriminate between stranger and neighbor vocalizations at leks, responding more quickly to strangers.
Maria Kuzmik, Ophélie Courtin, Christophe Klopp…·Sylvain Merlot
This study improves genome assemblies of Noccaea caerulescens accessions and identifies gene copy number variations linked to metal hyperaccumulation and adaptation.
Frederik Völker, Michael Kohlstedt, Birthe Halmschlag…·Lars M. Blank
Burcu Sırmatel, Fuat Balcı, Sertaç Üstün, Metehan Çíçek
This study shows that neural substrates for space, time, and numerosity overlap more during target encoding than during reproduction and performance evaluation phases.
Zilong Ji, Huiwen Zhang, Krishna Gorantla, Neil Burgess
This paper introduces a hierarchical RNN that mimics spatial navigation circuits, reproducing key cell types and dynamics through task-driven learning.
Alice M Xue, Jenna Jokhani, Anthony M. Norcia, Anthony D. Wagner
The paper shows that strong mnemonic prediction errors enhance cognitive control, attention, and arousal, leading to better learning of unexpected stimuli.
Aidan W. Porter, Allison E. Marciszyn, Hannah E. Vorndran…·Teresa M. Buck
This study shows that GRP170 protects podocytes from stress-induced glomerular injury by modulating the UPR, as demonstrated in a podocyte-specific knockout mouse model.
The paper adapts the Geometric Viability assay to measure C. difficile spore germination, finding it highly consistent with conventional methods and capable of detecting germination sensitivity differences.
Xiaoqing Hou, Honglei Wang, Panpan He…·Bao‐Jian Ding
The paper reconstructs a rare Δ10 desaturation pathway in Camelina sativa to produce yellow peach moth pheromone precursors, achieving up to 4.7% target fatty acids in seeds.
The paper develops function-oriented microglial transcriptional scores to capture post-activation functions in Alzheimer's disease, validated across multiple endpoints and datasets.
Bo Peng Zhou, Tony LH Chu, Aidan K. Gallant…·Christopher A. Maxwell
This study identifies Aurora kinase A's role in promoting collective cell invasion and metastasis by enabling leader cell phenotypes and stabilizing cohesion with follower cells.
Kangcheng Hou, Hui Li, Emily Nason…·Luke Jen O’Connor
The paper introduces KASM to integrate functional annotations and estimate heritability of rare protein coding variants across 786,871 exomes, finding higher heritability than previous estimates.
Julien Andréani, Miguel F. Romero, Sofia medvedeva…·Bernard LA SCOLA
The paper describes Sissivirus, a giant virus with a 4-megabase genome and a large repeatome, identifying repeat accumulation as a key driver of its genome expansion.
Yuqi Zhang, Danni Chen, Tao Xia…·Xiaoqing Hu
This study shows that sleep reactivation enhances memory for event content but impairs temporal-order memory, with effects varying over time.
Stijn V. Weckesser, Nataša Mišković, Mirja Thomsen…·Katja Lohmann
This study identifies a CAG repeat expansion in EP400 as a novel cause of spinocerebellar ataxia in Serbian patients, with an inverse correlation between repeat number and age at onset.
Swathi Murthy, Elena Bollati, Anya Salih, Michael Kühl
The paper models how coral host pigments affect light propagation and tissue heating, showing distinct roles of chromoproteins and fluorescent proteins in energy distribution and heat generation.
George Winder, Owen Somhorst, Erika Castaneda-Sastre…·Jeanne Salje
This study identifies the absence of lipoprotein biosynthesis machinery in Orientia tsutsugamushi and describes alternative mechanisms for its proteins.
Yongkang Li, Scott C. Schmidler
This paper introduces a Bayesian variable selection method for identifying selection in phylogenetic datasets, showing it outperforms Dirichlet-process models and avoids phantom selection artifacts.