Jeanne Salje

Complete loss of lipoprotein biosynthesis machinery in an obligate intracellular bacterium

This study identifies the absence of lipoprotein biosynthesis machinery in Orientia tsutsugamushi and describes alternative mechanisms for its proteins.

Symmetric Inheritance of the Cytoplasmic Bacterium Orientia tsutsugamushi During Mitosis

This study shows how two Rickettsiales bacteria, Orientia tsutsugamushi and Rickettsia rhipicephali, distribute during host cell division, with O. tsutsugamushi using microtubules for symmetric inheritance and R. rhipicephali inhibiting mitosis.

Gentamicin Treatment in a Murine Infection Model Suggests Extracellular Orientia tsutsugamushi Contributes to Systemic Dissemination

This study shows extracellular Orientia tsutsugamushi contributes to systemic dissemination and that gentamicin reduces bacterial growth in a murine model.

High levels of antisense transcription from numerous genes in the obligate intracellular bacterium Orientia tsutsugamushi.

The paper confirms high levels of antisense transcription in Orientia tsutsugamushi across multiple strains and suggests it may be a regulated mechanism in its lifecycle.

A genome-wide RNAi screen identifies host cell cycle regulation as a determinant of Orientia tsutsugamushi infection

Morphological and molecular characterisation of Orientia tsutsugamushi grown in tick cells

This study characterizes the morphology and molecular behavior of Orientia tsutsugamushi in tick cell lines, revealing distinct replication dynamics and protein expression patterns compared to mammalian cells.

Developmental Progression and Single-Cell Heterogeneity of Orientia tsutsugamushi during Intracellular Infection

This study identifies four distinct growth stages of Orientia tsutsugamushi within host cells using single-cell analysis, revealing asynchronous growth and transcriptional/translation heterogeneity.

Comparative Dual RNA-Seq Analysis of Eight Orientia tsutsugamushi Strains in Endothelial Cells Reveals Regulatory Patterns in Bacterial and Host Pathways During Infection

The paper compares dual RNA-seq data from eight Orientia tsutsugamushi strains in endothelial cells, finding no clear gene expression patterns correlating with virulence but identifying strain-specific interferon responses and conserved bacterial pathways.

The intracellular bacterium Orientia tsutsugamushi hijacks the adaptor protein BICD2 for dynein-based motility

This study identifies how Orientia tsutsugamushi uses ScaC to recruit BICD2 for dynein-based motility, revealing a mechanism for bacterial transport within host cells.

Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease.

This study compares seven strains of Orientia tsutsugamushi to identify virulence factors, finding no single gene or pattern predicts virulence, but highlighting complex interactions among effector proteins.

A comparison of super-resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium

This study compares super-resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium, finding 3D-STED best for axial resolution and differences in bacterial shape across cell lines.

Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen Orientia tsutsugamushi

The paper reports high-quality genomes of six Orientia tsutsugamushi strains using long-read sequencing and identifies a small core genome and phylogenetic relationships.