Discover, rate, and discuss biology preprints.

This paper introduces NLG4, self-assembled nucleolipid G-quadruplexes that inhibit pancreatic cancer by targeting multiple oncogenes and pathways.

This study shows that N-acetylcysteine amide reduces stress behavior in zebrafish with a reactive coping style but not proactive, highlighting the role of antioxidant mechanisms in stress responses.

The paper shows that mitochondrial pyruvate transport and endocytosis regulate the cell jamming transition in epithelial tissues.

DATRASextra provides an R package for processing and analysing DATRAS bottom-trawl survey data with modular workflows for data integration and analysis.

This study quantifies bone loss and histopathological changes in a mouse implant infection model, showing host-driven bone remodeling and correlations with bacterial:host genome ratios.

The paper creates a single-cell and spatial transcriptomics atlas of the ileum during diverse infections, revealing novel cell states and immune responses.

This study shows that RGF1 peptide signaling via ROS regulates root meristem development in Arabidopsis and rice, with conserved function across dicots and monocots.

This study identifies indole-3-propionic acid (IPA) as a gut microbiota-derived metabolite that prevents post-stroke cognitive impairment by preserving catecholamines in the dorsal hippocampus.

A rapidly evolving essential protamine suppresses sex-chromosome meiotic drive in Drosophila.

The paper uses linear morphometrics to test sexual dimorphism in Uintatherium anceps and finds no strong evidence of it, contrasting with findings in Bison bison.

The paper characterizes and engineers a bistable cnidopsin from a coral that can switch between states using different light wavelengths, showing potential as an optogenetic tool for regulating Gs-signaling.

This study measures how wind and currents affect the drift velocity of macrophytes and macroplastic particles and develops models to predict their movement.

The paper analyzes the navigability of random fitness landscapes, showing that adaptive basins are large and increase with fitness rank.

The paper uses biased Fab phage-display libraries and computational methods to identify potent serine protease inhibitors and validate their binding interactions.

This study compares the effects of sleep deprivation and dual-task walking on gait parameters, finding distinct impacts on movement stability and variability.

The paper identifies expressed endogenous retroviral element long terminal repeats (ERV LTRs) in devil facial tumour cells and validates them as potential vaccine targets.

The paper develops a normative modeling framework for four rsfMRI metrics across age and sex, showing age-related declines and regional variability.

This study shows that Monarch butterflies use visual cue properties to switch between attraction to terrestrial landmarks and menotactic orientation to celestial cues during navigation.

The paper introduces optimized fluorescence-activated nuclei sorting (FANS) protocols to isolate cell-type-specific nuclei from human and mouse brain tissue for multi-omic analysis.

This study shows that deleting Scp160 reduces TDP-43 aggregation and toxicity in yeast, while Bfr1 has a lesser effect.