Joan Castells-Ballester

The paper discovers a novel archaeal AP endonuclease from a salt marsh metagenome using cell-free functional metagenomics, showing its high salt tolerance and structural similarity to human APE1.

This study shows that deleting Scp160 reduces TDP-43 aggregation and toxicity in yeast, while Bfr1 has a lesser effect.

The paper develops a microdroplet-based functional genomic screening pipeline using DNA nanoflowers and cell-free expression to identify DNA-interacting enzymes.

The paper identifies Bfr1 as a regulator of Pmt1 and Pmt2 translation, affecting unfolded protein O-mannosylation in yeast.