Joachim Krug

Mutation-biased adaptation: The Yampolsky-Stoltzfus model revisited

The paper derives closed-form approximations for the probability of mutationally favored genotypes fixing in finite populations with appreciable mutation supply, improving upon previous limiting cases.

Random Fitness Landscapes are Highly Navigable

The paper analyzes the navigability of random fitness landscapes, showing that adaptive basins are large and increase with fitness rank.

Experimental evolution of collective β-lactam resistance in Escherichia coli via activation of a dormant outermembrane porin

This study shows that increased collective β-lactam resistance in E. coli arises from activation of a dormant porin, NmpC, through an insertion sequence excision, enhancing drug permeability and filamentation.

Contributions of intra- and extracellular antibioticdegradation to collective β-lactam survival

The paper investigates how intra- and extracellular β-lactamase activity contributes to collective β-lactam survival in E. coli under cefotaxime stress.

Adaptive Dynamics of Quantitative Traits in a SteadilyChanging Environment

This study investigates how environmental change speed and trait architecture influence adaptive dynamics using models and simulations, revealing critical thresholds and genetic equilibrium mechanisms.

Population structure amplifies mutation load

The paper shows that spatial structure amplifies mutation load, reducing the effectiveness of natural selection and promoting the proliferation of less-fit types in structured populations.

Epistasis-mediated compensatory evolution in a fitness landscape with adaptational tradeoffs

The paper models compensatory evolution in a fitness landscape with adaptational tradeoffs, showing that resistance mutations can be replaced by lower-cost variants without losing resistance.

Graph-structured populations elucidate the role of deleterious mutations in long-term evolution

The paper investigates how spatial structure affects evolutionary outcomes by identifying amplifier and suppressor graphs for mutant fixation and their impact on long-term fitness.

Superposition of survival curves as a tool for epistasis analysis of longevity interventions

The paper introduces a method to analyze epistasis in longevity interventions by comparing observed survival curves to predicted ones, finding weak epistasis in C. elegans.