Discover, rate, and discuss biology preprints.

The paper shows that coarse-grained connectome partitions can preserve functional predictions about neural activity even when path structure is lost.

This study shows that transient ATF4 activation in neurons during early adulthood extends healthspan and promotes systemic adaptations in Drosophila.

This paper introduces a three-step workflow using segmented regression to improve semi-mechanistic pharmacodynamic modeling of antibiotic effects, demonstrating it with colistin against Pseudomonas aeruginosa.

The paper develops a biosensor platform using monomeric streptavidin to evaluate binding domains for small molecules and proteins, demonstrating ligand-dependent activation with biotinylated targets.

LRCP identifies functionally related SNPs and genes by estimating phenome-wide genetic-effect correlations from GWAS summary statistics, improving accuracy over naive methods.

This study examines evolutionary and acclimatory shifts in gene expression of ion transporters in Eurytemora carolleeae across salinity transitions using quantitative PCR.

The paper identifies sex-specific bone marrow cell populations that regulate bone mass and shows CD74 marks osteoclast precursor subsets.

This study identifies podoplanin's role in maintaining epidermal organisation and coordinating stem cell and dermal responses during inflammatory skin remodelling.

Rho is a collaborative analysis environment that organizes materials by scientific purpose to support human-AI judgment in bioinformatics.

The paper shows that locomotion enhances visuo-frontal communication, improving visual processing and behavioral performance in macaques.

CARTnet improves B-cell epitope prediction using a contact-aware deep learning framework, outperforming existing methods on internal and external datasets.

This study investigates the role of dopamine afferents to the ventral pallidum in reward processing using circuit tracing, fibre photometry, and behavioural pharmacology in male rats.

This paper develops a dual-targeting liposomal nanoplatform for glioblastoma treatment, showing improved drug delivery across the BBB and enhanced tumor suppression.

This study investigates virus coinfection in plants by analyzing environmental and ecological factors across multiple host species and communities, finding that most coinfections are random interactions driven by environmental responses.

The paper compares RNA sequencing protocols using long-read sequencing, finding significant changes in isoform structure and abundance due to RNA processing steps.

This paper investigates the structural feasibility of squalene interacting with the KEAP1 Kelch domain using molecular docking and provides a hypothesis for its role in NRF2 regulation under stress.

This study shows antibiotic-induced envelope stress in Salmonella disrupts compartmentalization, enabling PBP5 and ACP interaction that drives hypervesiculation.

This study introduces QUEST, a model that uses H&E histology to predict spatial protein expression, enabling virtual staining and analysis across biological scales.

ALIGN provides a modular framework for analyzing longitudinal development in C. elegans, enabling accurate segmentation, quality control, and motion correction across imaging conditions.

The paper shows that environmental-induced phenotypic plasticity can promote coexistence in antagonistic bacterial species by spatial segregation, but removing this segregation leads to higher coexistence through adaptive plasticity.