Neuronal titration of Snca via enhancer disruption mitigates disease onset in a Parkinson's disease mouse model
Rachel J. Boyd, A Ra Kho, Sarah A. McClymont, Stacie K. Loftus, Han Seok Ko, Andrew S. McCallion
This study shows that disrupting a Snca enhancer in mice reduces Snca expression and protects against Parkinson's disease pathology and motor impairments.
Brain · Jan 6, 2026Peer-reviewedGenetics